My Little Sister Can't Possibly Have a Hemorrhoid?!

My Little Sister Can't Possibly Have a Hemorrhoid?! is an adult visual novel with a title and premise that leaves nothing to the imagination. The protagonist is Atsushi Ichinose, a young man who finds himself in an awkward dilemma when his younger sister Miu asks him for help inserting a rectal suppository to alleviate her hemorrhoid. The intimacy of the situation awakens hidden desires inside Atsushi and they end up having sex. Miu's best friend Kana is also drawn into the madness when she learns about their situation.

Like most visual novels, the gameplay consists of reading text atop of illustrated backgrounds and periodically making a decision through the eyes of the protagonist, though My Little Sister... contains few choices to make. The game features voice acting for the main female characters only.